The Journal of Phytopharmacology 2024; 13(1):12-19 DOI:10.31254/phyto.2024.13103

Research Article

Identification of Hsp90 inhibitors from Ananas comosus potential phytochemicals for lung cancer treatment

Mudassir Alam¹ , Kashif Abbas¹ , Abrar Ahmad¹ , Nowsheen Showkat¹ , Rima Sen²

Mudassir Alam,Kashif Abbas,Abrar Ahmad,Nowsheen Showkat,Rima Sen

1. Department of Zoology, Aligarh Muslim University, Aligarh, Uttar Pradesh-202002, India
2. Department of Biosciences & Biomedical Engineering, Indian Institute of Technology (IIT), Indore, Madhya Pradesh- 453552, India

*Author to whom correspondence should be addressed.

Received: 13th January, 2024 / Accepted: 23rd February, 2024

Abstract

Lung cancer is a significant global health issue, with thousands of lives lost each year. One potential approach to preventing lung cancer is the use of heat shock protein 90 (Hsp90) inhibitors, which have been shown to induce substantial cell death in both chemo-sensitive and chemo-resistant small cell lung cancer cells. In this study, we conducted in silico computational molecular docking of pineapple phytochemicals with Hsp90 to investigate their potential inhibitory effects on Hsp90 and, consequently, their ability to prevent lung cancer. Our findings demonstrate that the phytochemicals found in Ananas comosus, specifically caffeic acid, ferulic acid, 4-Hydroxycinnamic acid, Sinapic acid, and D-Galacturonic Acid, exhibit notable inhibitory activity against Hsp90. Beyond their Hsp90 inhibition, these phytochemicals also demonstrate promising biological activities, serving as effective agents against neoplastic conditions, particularly lung cancer, and displaying pro-apoptotic properties. Moreover, the ADME (Absorption, Distribution, Metabolism, and Excretion) and toxicological assessments conducted on these compounds yielded satisfactory results. These findings suggest that pineapple phytochemicals may have potential in the development of novel therapeutic strategies for lung cancer prevention.